You Position: Home > Paper

Relationship between the angiotensin converting enzyme 2 gene polymorphism and antihypertensive effect of valsartan

( views:271, downloads:36 )
Author:
No author available
Journal Title:
Journal of Chinese Physician
Issue:
7
DOI:
10.3760/cma.j.issn.1008-1372.2012.07.002
Key Word:
高血压/代谢/遗传学/治疗;缬氨酸/类似物和衍生物/药理学;血管紧张素转换酶2/代谢/遗传学;多态性,单核苷酸;Hypertension/metabolism/genetics/therapy;Valine/analogs & derivatives/pharmacology;Angiotensin-converting enzyme type 2/metabolism/genetics;Polymorphism,single nucleotide

Abstract: Objective To study the relationship of single nucleotide polymorphism of angiotensin converting enzyme 2 ( ACE2 ) with essential hypertension(EH) and antihypertensive response of valsartan.Methods A total of 120 case EH patients was received valsartan once daily for four weeks.Direct DNA sequencing was performed to detect the signgle nucleotide polymorphisms of ACE2 in 120 EH patients and 60 controls with normal blood pressure.Results The genotyping data indicated that there were significant differences of G allele frequency between male or female EH group and controls( x2 =5.310,4.423,P <0.05 ).Treated with valsartan,patients with.G allele were not found to be associated with reduction in blood pressure( P >0.05).Conclusions Our data suggest that the ACE2 G8790A signgle nucleotide polymorphisms might be involved in the development of EH.The risk developing hypertension in the people carrying G allele is higher than that in those carrying other allele.Therefore,ACE2 gene might be a sensitive gene associated with EH.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn