You Position: Home > Paper

TESTIN tumor suppressor gene in endometrial cancer tissues

( views:606, downloads:16 )
Author:
No author available
Journal Title:
Journal of Chinese Physician
Issue:
11
DOI:
10.3760/cma.j.issn.1008-1372.2011.11.004
Key Word:
基因,肿瘤抑制;子宫内膜肿瘤/代谢;Genes,tumor suppressor;Endometrial neoplasms/ME

Abstract: Objective To investigate the expression of TESTIN gene in endometrial carcinoma and explore the functions of this gene in tumor development and progression.Methods qRT-PCR and immunochemical staining assay were used to determine the mRNA and protein level of TESTIN in the tumor tissues,and the relationship between TESTIN expression and clinical pathology characteristics was analyzed.Results Compared to normal tissue,76.5% (52/68) tumor tissues showed TESTIN reduced ( P < 0.01 ),furthermore,this reduction in the subgroup of endometrioid adenocarcinoma was significant,but it was rarely observed in the subgroup of serous papillary adenocarcinoma.Conclusions TESTIN was obviously down regulated in endometrail carcinoma,especially in endometrioid adenocarcinoma,which indicated TESTIN played an important role in tumorigenesis of uterine.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn