You Position: Home > Paper

Study on the expression of Glut1, HIF-1α and Ki-67 in hepatocellular carcinoma and their relationship

( views:478, downloads:80 )
Author:
No author available
Journal Title:
Journal of Chinese Physician
Issue:
8
DOI:
10.3760/cma.j.issn.1008-1372.2011.08.004
Key Word:
葡萄糖转运蛋白质类,易化性/代谢;缺氧诱导因子1/代谢;Ki-67抗原/代谢;癌,肝细胞/代谢;Glucose transport proteins,facilitative/ME,Hypoxia-inducible factor 1/ME;Ki-67antigen/ME;Carcinoma,hepatocellular/ME

Abstract: Objective To explore the expression of Glut1, HIF-1α and Ki-67 in hepatocellular carcinoma (HCC) and their relationship between their expression and clinicopathological features.Methods Immunohistochemical study (EnVision method) for Glut1, HIF-1a and Ki-67 were performed on tissue microarray which consisted of 171 cases of HCC, 55 cases of adjacent non-neoplastic liver tissues, and 22cases of normal liver tissues.Results The expression rate of Glut1 ,HIF-1α and ki-67 in 171 cases of HCC was 15.2%, 19.9% and 66.1%, respectively, which was much higher than that in the adjacent non-neoplastic liver tissues (1.8% ,1.8%and 5.5%) and normal liver tissues(all negative).The expressions of Glut1 and HIF-1α were positively correlated with the differentiation degree of HCC and TNM stage(P <0.01, P <0.05).The expression of ki-67 was positively correlated with the differentiation degree of HCC.There was a significant positive correlation between the expressions of Glut1 and HIF-1α in HCC (r1 =0.553, P <0.05), the expressions of Glut1 and HIF-1α were positively correlated with ki-67(r2 =0.560,r3 =0.613, P <0.05).Conclusions Glut1, HIF-1α and ki-67 may play a role in the tumorigenesis and progression of HCC in some degree.Combined detection of Glut1, HIF-1α and Ki-67 may be helpful to judge the degree of malignancy and potential metastasis and evaluate the prognosis.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn