You Position: Home > Paper

The observation of the influence about left heart function in obstructive sleep apnea by chronic intermittent hypoxia

( views:229, downloads:21 )
Author:
No author available
Journal Title:
JOURNAL OF CHINESE PHYSICIAN
Issue:
5
DOI:
10.3760/cma.j.issn.1008-1372.2010.05.002
Key Word:
缺氧;睡眠呼吸暂停,阻塞性/并发症/治疗;心室功能,左;正压呼吸;Anoxia;Sleep apnea,Obstructive/CO/TH;Ventricular function,left;Positive-pressure respiration

Abstract: Objective To investigate the influence of left heart function in obstructive sleep apnea by CIH, and explore left heart function before and after CPAP. Methods 75 OSA were divided into two groups. Blood pressures of 40 patients were coincident with diagnostic standard of hypertension and 35 patients did not have hypertension. The control group included 30 healthy adults. The blood pressures before and after sleep, left ventricular ejection fraction(LVEF) ,shortening fraction(FS) , E, A and E/A were compared with those of normal control subjects. BP, LVEF and E/A after CPAP were also analyzed. Results Multiple parameters including LVEF[ ( 56.40 ±9.74)% ] , FS[ (33. 80 ±6.16)% ] and E/A (0. 87 ±0.17) , were impaired in OSA patients relative to the control subjects ( P <0. 05 orP <0.01). E/A was significantly decreased in obstructive sleep apnea unallied hypertension than that in normal control subjects. E/A was conspicuously decreased in obstructive sleep apnea patients associated hypertension comparing with that in obstructive sleep apnea unallied hypertension. After CPAP for 6 months, in these obstructive sleep apnea associated hypertension patients, LVEF [(59.70 ±11. 1)%] was increased than that before treatment[ (56. 40 ± 9.74)% ] ( P <0.05), and E/A (1.16 ± 0. 25 ) was higher than that before treatment (0. 87 ±0. 17) ( P <0.01). Conclusion CIH may affect left heart structure and function. These changes were aggravated with hypertension. CPAP treatment had important effects in the treatment of cardiovascular function, and it could improve the life quality.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn