Expression of PTTG and its relationship with bFGF and MVD in esophageal carcinoma
- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1008-1372.2008.09.004
- Key Word:
- 食管肿瘤;肿瘤蛋白质类;垂体肿瘤;成纤维细胞生长因子2;毛细血管;Esophageal neoplasms;Neoplasm proteins;Pituitary neoplasms;Fibroblast growth factor 2;Capillaries
Abstract： Objective To study the expressions of PTTG and bFGF proteins and their relationship with microvessels density(MVD)in esophageal carcinoma.Methods Immunohistochemical SP method was used to detect the expression of PTTG and bFGF proteins in 48 esophageal carcinoma tissues and the same para-cancerous tissues.MVD was evaluated by immunohistochemieal staining with antibody CD34.Results The positive rate of PTTG and bFGF was 68.8%(33/48)and 70.8%(34/48)respectively.Rate of PTTG protein expression in esophageal carcinoma tissues was significantly higher than that in para-cancerous tissues(8.3%and 12.5%,P＜0.05).The positive rate 0f PTTG,bFGF and MVD was correlated with lymph node metastasis and TNM stage.There was no relationship with age,sex,tumor size MVD(P＜0.05).Conclusion PTTG and bFGF are over-expressed in esophageal carcinoma.Increased PTTG may play an important role in carcinogenesis and development of esophageal carcinoma by promoting the expression of bFGF protein which may induce an angiogenesis.
- [1]杨竹林,苗雄鹰,钟德玝,等.胰腺癌和慢性胰腺炎组织中垂体肿瘤转化基因mRNA和脆性组氨酸三联体表达研究[J].2006,(6).
- [2]郑兆斌,彭品贤,梁健辉.微血管密度与淋巴结微转移作为食管癌分期补充参数的探讨[J].2006,(2).
- [3]Ma EL,Wang MW,Xia MY,etc.Beta-eudesmol suppresses tumour growth through inhibition of tumour neovascularisation and tumour cell proliferation.[J].2008,10(1).
- [4]TAKESHI ITO,KENJI ASHIDA,HIDETAKA MORINAGA,etc.Human Pituitary Tumor Transforming Gene (hPTTG) Inhibits Human Lung Cancer A549 Cell Growth through Activation of p21~(WAF1/CIP1)[J].2003,50(6).
- [5]Run, Yu,Shlomo, Melmed.Pituitary tumor transforming gene: an update.[J].2004,32.
- [6]Kanuparthi D,Chattopadhyay N,Tfelt-Hansen J.The emerging role of pituitary tumor transforming gene in tumorigenesis.[J].2006,4(2).
- [7]Pei L.,Melmed S..Isolation and Characterization of a Pituitary Tumor-Transforming Gene (Pttg)[J].1997,11(4).
- [8]Nina, Rehfeld,Helene, Geddert,Abedelsalam, Atamna,etc.The influence of the pituitary tumor transforming gene-1 (PTTG-1) on survival of patients with small cell lung cancer and non-small cell lung cancer.[J].2006,5.