Effects of fluvastatin on the expression of transforming growth factor β1 in the kidney of diabetic rats
- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-1372.2008.05.004
- Key Word:
- 糖尿病;普伐他丁/药理学;肾/药物作用;Diabetes mellitus;Pravastatin/PD;Kidney/DE
Abstract： Objective To study the protective effects of fluvastatin on the renal lesions in diabetic rat. Methods The model of diabetic rats was induced by streptozotocin. SD rats were random divided into four groups: Control group, diabetic rats group, low-dose fluvastatin group 2mg/(kg·d) and high-dose fluvastatin group 4 mg/(kg·d). After treatment for 4 weeks, serum cholesterol, serum creatinine and urinary protein were measured respectively. The expression of TGF β1 in the renal cortex was determined by RT-PCR. Results Fluvastatin inhibited the expression of TGF-β1 Mrna in a dose-dependent manner, and had no influence on urinary protein, serum cholesterol and serum creatinine. Conclusions Fluvastatin inhibits the overexpression of TGF-β1 Mrna, which may be related to independent cholesterol decreasing effect.
- [1]Hohl RJ,Wohlford Lenane CL,Holstein SA.Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB.[J].2002,277(12).
- [2]Tanaka K,Katoh M,Doi H,etc.Fluvastatin inhibits O2- and ICAM-1 levels in a rat model with aortic remodeling induced by pressure overload.[J].2001,281(2).
- [3]Baibaswata Nayak,Guanosine triphosphate-binding proteins,Advanced glycation end products,etc.Cell Biology of Diabetic Kidney Disease[J].2005,101(3).
- [4]Matsuda M,Ogawa D,Shikata K,etc.HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats.[J].2003,18(2).