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Protective effects of octreotide on ischemic-reperfusion injury for resection of liver

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Author:
No author available
Journal Title:
JOURNAL OF CHINESE PHYSICIAN
Issue:
3
DOI:
10.3760/cma.j.issn.1008-1372.2008.03.005
Key Word:
奥曲肽/药理学;肝切除术;再灌注损伤/预防和控制;缺血预处理;Octreotide/PD;Hepatectomy;Reperfusion injury/PC;Ischemic preconditioning

Abstract: Objective To study the protective effect of Octreotide against ischemia-reperfusion injury when liver was resected Methods Using the routine Pringle's maneuver hepaticvaseular occlusion,thirty patients for resection of liver with cirrhosis were random divided into two groups:octreotide group(n=15)and physiologic saline group(n=15).In octreotide group,the patients with hepatecto15),the patients were injected 1ml saline in the same way.The variations of postoperative liver function were measured.Plasma MDA and TNF-α after reperfusion for 1h were measured and the hepatic histopathologic alterations were also examined.Results The levels of ALT and AST from the octreotide group increased less than those of the physiologic saline group(P<0.01).Meanwhile,Plasma MDA and TNF-α from the octreotide group was slightly increased(P<0.01)and the hepatic histopathologic alterations were significantly decreased.Conclusions Given octreotide by subcutaneous injection before blocking portabepatis show all important protective effect against the hepatic isehemia-repedusion injury for resection of liver.

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