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Expression of EGFR and p21WAF1 oncoprotein in condyloma acuminata lesions
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1008-1372.2007.11.003
- Key Word:
- 尖锐湿疣;生殖器疾病,女(雌)性;受体,表皮生长因子;原癌基因蛋白质p21(ras)
Abstract： 目的 探讨表皮生长因子受体(EGFR)及p21WAF1蛋白在尖锐湿疣(CA)发病机制中的作用以及两者的对应关系.方法 采用免疫组化SP法检测60例CA(外阴CA和宫颈CA各30例)皮损中EGFR和p21WAF1的原位表达,并以15例健康男性正常包皮组织及15例女性正常宫颈组织作为对照.结果 CA组和对照组EGFR表达阳性率差异无统计学意义(P＞0.05),但CA组EGFR过度表达率显著高于对照组(P=0.000);p21WAF1阳性表达率CA组低于对照组(P＜0.05),CA组中EGFR与p21WAF1表达负相关(r=-0.963,P＜0.01).结论 EGFR与p21WAF1表达缺失与CA的发病机制有关.
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