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The effect of electroacupuncture on GAP-43 expression of ischemic brain and infarct volume in MCAO rat

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Author:
No author available
Journal Title:
JOURNAL OF CHINESE PHYSICIAN
Issue:
10
DOI:
10.3760/cma.j.issn.1008-1372.2007.10.005
Key Word:
电针△;脑梗塞;GAP-43蛋白

Abstract: 目的 观察电针对缺血再灌大鼠脑内生长相关蛋白-43(GAP-43)表达和脑梗死体积的影响.方法 实验分假手术组、缺血再灌组和缺血再灌+电针组,大脑中动脉线栓(MCAO)造成局灶性缺血90 min,电针组在缺血后立即给予电针1 h(取穴为"人中"和"百会",强度3.5 mA,频率100Hz),以后1次/d.在缺血再灌1、7和14 d分别处死,进行免疫组织化学、Western blot,在再灌后14d进行神经功能评分和TTC染色.结果 GAP-43主要在缺血灶周围的皮质表达.在再灌后7和14 d后电针组GAPP-43免疫阳性细胞数和蛋白水平高于缺血组(P<0.05).同时神经学功能评分和TTC染色结果表明,电针组神经功能评分优于缺血组,且梗死体积小于缺血组.结论 电针能够提高GAP-43在缺血灶周围皮质的表达,从而促进缺血后轴突的出芽和突触再生,提高了缺血后神经元可塑性.

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