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The effects of ligustrazine on experimental osteoarthritis in rabbit model
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1008-1372.2007.09.004
- Key Word:
- 川芎嗪/药理学;骨关节炎/中药疗法;注射,关节内
Abstract： 目的 观察川芎嗪注射液对兔骨关节炎模型的治疗作用.方法 12只新西兰兔,利用Hulth法建立兔膝关节的骨关节炎模型.术后4周膝关节腔内给药.依照注射药物不同将24只膝关节分为A组(川芎嗪组),B组(透明质酸钠组),C组(生理盐水组).注药4周后,处死动物,采用组织学方法和透射电镜技术观察膝关节软骨组织的退变情况.结果 川芎嗪组和透明质酸钠组膝关节骨关节炎的病变程度明显轻于生理盐水组(P＜0.05);川芎嗪组和透明质酸钠组骨关节炎的病变程度差异无统计学意义(P＞0.05).结论 川芎嗪能明显减轻兔骨关节炎的病变程度.
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