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The relationship of transmissibility in Helicobacter pylori and primary gastric carcinoma
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1008-1372.2007.08.005
- Key Word:
- 螺杆菌,幽门;高血压,胃肿瘤/病理学/遗传学;微卫星重复;杂合子丢失;染色体
Abstract： 目的 分析人19染色体短臂上的微卫星不稳定性(MSI)和杂合性丢失(LOH)与幽门螺杆菌(Hp)感染之间的关系,探讨幽门螺杆菌遗传毒性在胃癌中的作用.方法 PCR检测Hp在胃癌中的感染情况,进一步分析Hp感染患者中Hp基因CagA的表达缺失情况,探讨Hp感染及CagA基因表达与19p微卫星之间的关系.结果 在79例胃癌患者中,86.1%(68/79)患者为Hp阳性,CagA基因阳性率为83.82%(57/68).而CagA基因的表达与19p遗传不稳定性相关,这种杂合性丢失与原发性胃癌的临床分期及远处转移相关,且随着恶性程度增加LOH频率也增加(P＜0.01).结论 Hp感染与19p高频率的LOH相关,可能通过19p区域的肿瘤抑癌基因参与胃癌的发生和进展.
- [1]Sipponen P,Sajantila A,Vauhkonen M,etc.Differences in genomic instability between intestinal- and diffuse-type gastric cancer.[J].2005,8(4).
- [2]Rodrigo Oliva, Perez,Carlos Eduardo, Jacob,Fabricio L'ofreddo, D'Ottaviano,etc.Microsatellite instability in solitary and sporadic gastric cancer.[J].2004,59(5).
- [3]Yoshihara M,Ito M,Hiyama T,etc.Chromosomal and microsatellite instability in sporadic gastric cancer.[J].2004,19(7).
- [4]Pelayo Correa,William Haenszel,Carlos Cuello,etc.A Model for Gastric Cancer Epidemiology[J].1975,306(7924).
- [5]Yokozaki H,Semba S,Wu M,etc.Molecular pathological analysis of mucinous adenocarcinomas of the stomach.[J].2004,71(4).
- [6]David, Shibata,Yuriko, Mori,Kun, Cai,etc.RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomas.[J].2006,119(4).