You Position: Home > Paper
The relationship between angiotensin converting enzyme gene polymorphism and the improved effect of perindopril on endothelial dysfunction of brachial artery in hypertensive patients
( views:246, downloads:8 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1008-1372.2007.07.002
- Key Word:
- 肽基二肽酶A;多态现象,遗传;吲哚类/治疗应用;高血压/药物疗法;肱动脉;内皮
Abstract： 目的 探讨培垛普利对高血压患者肱动脉内皮舒张功能障碍的干预作用以及血管紧张素转换酶(ACE)基因的插入/缺失(I/D)多态性对这种干预作用的影响.方法 以87名无合并症的老年原发性高血压患者(高血压组)和50名正常老年人(对照组)作为研究对象,用高分辨超声技术检测研究对象的肱动脉内皮舒张功能,用聚合酶链反应(PCR)方法检测研究对象的ACE基因I/D多态性.高血压组在接受培垛普利治疗12周后复测肱动脉内皮舒张功能.结果 高血压组三个基因型亚组的内皮依赖舒张功能与对照组对应的三个基因型亚组比较均有显著减退(P＜0.01).无论是高血压组还是对照组,具有DD基因型个体的肱动脉内皮依赖舒张功能均显著低于Ⅱ型个体(P＜0.05).在高血压组,培垛普利治疗后三个基因型亚组的肱动脉内皮依赖舒张功能与治疗前比较均有显著改善(P＜0.01),改善幅度DD＞ID＞Ⅱ型,DD型或ID型与Ⅱ型亚组比较差异有统计学意义(P＜0.01).结论 培垛普利能逆转老年高血压患者的肱动脉内皮依赖舒张功能障碍,含有D等位基因的患者获益更大.
- [1]张俊,罗开良,刘增长,等.高血压患者脉压与大动脉扩张性、内皮功能关系的研究[J].2003,(4).
- [2]戚本玲,管思明,柯琴梅,等.培哚普利对老年高血压患者颈动脉内-中膜厚度及血管内皮依赖性舒张功能的影响[J].2004,(12).
- [3]管永泽,李瑞华,郭荣芝.培哚普利美托洛尔和氨氯地平对原发性高血压血管内皮功能的影响[J].2004,(1).
- [4]张丽梅,郜健,王晓焕.培哚普利对老年高血压病患者血管内皮功能的影响[J].2005,(13).
- [5]Zingone A,Perticone F,Ceravolo R,etc.Angiotensin-converting enzyme gene polymorphism is associated with endothelium-dependent vasodilation in never treated hypertensive patients.[J].1998,31(4).
- [6]钟慈声,孙安阳.一氧化氮的生物医学[M].1999.
- [7]B, Rigat,C, Hubert,P, Corvol,etc.PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1).[J].1992,20(6).
- [8]Giacopelli F,Ravera M,Leoncini G,etc.Genetic polymorphism of the renin-angiotensin system and organ damage in essential hypertension.[J].2000,57(2).
- [9]D.S. Celermajer,K.E. Sorensen,V.M. Gooch,etc.Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis[J].1992,340(8828).
- [10]H, Buikema,Y M, Pinto,G, Rooks,etc.The deletion polymorphism of the angiotensin-converting enzyme gene is related to phenotypic differences in human arteries.[J].1996,17(5).