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Correlation study between postoperative multidrug resistance and hemoglobin concentration and the expression of hypoxia-inducible factor-1αin gastric cancer
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1008-1372.2007.03.002
- Key Word:
- 胃肿瘤;抗药性,多药;血红蛋白类;P糖蛋白;DNA拓扑异构酶类,Ⅱ型;谷胱甘肽转移酶;缺氧
Abstract： 目的 通过检测P-糖蛋白(P-gp)、拓扑异构酶-Ⅱ(TOPO-Ⅱ)、谷胱甘肽转移酶-π(GST-π)及缺氧诱导因子-1α(HIF-1α)在胃癌组织中的表达,探讨胃癌患者术后化疗多药耐药(MDR)与血红蛋白(Hb)浓度、HIF-1α表达水平的相关性及其可能的内在机制.方法 采用免疫组化方法检测56例胃癌组织及20例癌旁正常组织中P-gp、TOPO-Ⅱ、GST-π及HIF-1α的表达.结果 (1)胃癌组织P-gp、GST-π、HIF-1α表达水平高于癌旁正常组织,TOPO-Ⅱ表达水平低于癌旁正常组织(P＜0.05).(2)P-gp、GST-π在不同组织学类型之间差异有统计学意义,HIF-1α在不同癌肿浸润深度及有、无淋巴结转移之间差异有统计学意义(P＜0.05).(3)在胃癌组织中,P-gp、GST-π及HIF-1α表达水平与Hb成正相关,TOPO-Ⅱ表达水平与Hb呈负相关,HIF-1α与P-gp表达水平之间呈正相关.结论 胃癌患者术后化疗MDR与Hb浓度、HIF-1α表迭水平成正相关,HIF-1α可能是贫血导致胃癌患者术后化疗MDR的介导因子之一.
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