You Position: Home > Paper
The expression of p38 mitogen activated protein kinase in rat pulmonary artery smooth muscle cells under hypoxia
( views:157, downloads:0 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1008-1372.2006.11.004
- Key Word:
- p38丝裂原活化蛋白激酶类;肺动脉;肌,平滑,血管;细胞增殖;细胞低氧
Abstract： 目的 探讨p38丝裂原活化蛋白激酶(p38MAPK)在低氧引起的鼠肺动脉平滑肌细胞增殖中的作用.方法 采用细胞培养方法,免疫印迹技术,流式细胞仪方法测定在低氧情况下p38 MAPK的表达及其细胞周期的变化.结果 低氧情况下细胞中p38 MAPK表达增加,细胞呈现增殖性变化.结论 p38 MAPK在低氧情况下参与了鼠肺动脉平滑肌细胞增殖,具有重要的病理生理学意义.
- [1].缺氧促使鼠气道平滑肌细胞丝裂原活化蛋白酶表达[J].2005,(19).
- [2]Haddad JJ.Hypoxia and the regulation of mitogen-activated protein kinases: gene transcription and the assessment of potential pharmacologic therapeutic interventions.[J].2004,4(10).
- [3]Carrera AC,Naranjo-Suarez S,Jimenez C,etc.Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis.[J].2001,276(25).
- [4]M, Karin.Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs.[J].2004,63 Suppl 2.