You Position: Home > Paper
Early diagnosis and prognostic value of a qualitative test for heart-type fatty acid-binding protein in patients with acute coronary syndrome(ACS)
( views:227, downloads:8 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1008-1372.2006.11.002
- Key Word:
- 载体蛋白质类/诊断应用;脂肪酸类/诊断应用;冠状动脉疾病/诊断
Abstract： 目的 探讨心型脂肪酸结合蛋白(H-FABP)对非ST段抬高急性冠脉综合征(ACS)早期诊断及预后判定的价值.方法 测定268例胸痛患者血清H-FABP 和肌钙蛋白T(cTnT),对临床最终确诊的112例ACS患者H-FABP水平进行分析,并观察入院30 d内预后不良组(高危险组)患者H-FABP的变化.结果 胸痛出现3 h内,H-FABP和TnT检测ACS阳性率分别为49.1%和9.1%,二者差异有统计学意义(P＜0.001) .高危险组H-FABP阳性率94.7%,阴性率5.2%(P＜0.001).ACS患者危险分层越高,血清中H-FABP浓度越高.在校对了肌钙蛋白T、左心室射血分数等影响因素后,H-FABP仍是影响ACS患者预后的独立危险因素[95%可信区间,2.258(1.268～3.896)].结论 H-FABP对ACS早期诊断及预后判定具有重要临床价值.
- [1]王小平,马达,王万相,等.脂肪酸结合蛋白对急性心肌梗死早期诊断的价值[J].2001,(5).
- [2]中华心血管病杂志编辑委员会.不稳定性心绞痛诊断和治疗建议[J].2000,(6).
- [3]Hermens WT,Pelsers MM,Glatz JF.Fatty acid-binding proteins as plasma markers of tissue injury.[J].2005,352(1).
- [4]Shimamoto K,Nakata T,Hase M,etc.Human heart-type Fatty Acid-binding protein as an early diagnostic and prognostic marker in acute coronary syndrome.[J].2003,99(2).
- [5]J, Górski,W T, Hermens,J, Borawski,etc.Increased fatty acid-binding protein concentration in plasma of patients with chronic renal failure.[J].1997,43(1).