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Role of soluble vascular cell adhesion molecule-1 in the pathogenesis of hypertensive disorder complicating pregnancy and the outcome of pregnancy
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1008-1372.2006.09.003
- Key Word:
- 高血压,妊娠性;妊娠并发症,心血管;血管细胞黏附分子-1;妊娠结局
Abstract： 目的 研究可溶性血管细胞黏附分子1(sVCAM-1)在妊娠期高血压疾病(HDCP)发病中的作用及对妊娠结局的影响.方法 用酶联免疫吸附法(ELISA) 测定67例孕妇血清中sVCAM-1水平,其中正常妊娠组15例,HDCP组52例,包括妊娠期高血压(GH)14例、轻度子痫前期(MP)18例、重度子痫前期(SP)20例.结果 轻、重度子痫前期患者血中sVCAM-1水平显著高于正常妊娠组(P＜0.01),GH组患者与正常妊娠组相比,差异无统计学意义,但有升高趋势,HDCP组产后该指标下降,与正常妊娠组无统计学意义(P＞0.05).sVCAM-1浓度与平均动脉压呈正相关(r＝0.542,P＜0.01).sVCAM-1浓度与新生儿体重呈负相关(r＝-0.643,P＜0.01).结论 妊娠期高血压疾病患者血中sVCAM-1水平升高表明内皮细胞损伤在妊娠期高血压疾病发病中起重要作用.
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