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Expressions and significance of p16,p53 and proliferating cell nuclear antigen proteins in human astrocytomas
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1008-1372.2006.07.005
- Key Word:
- 神经胶质瘤;基因,p16;基因,p53;增殖细胞核抗原
Abstract： 目的探讨p16与p53及增殖细胞核抗原(PCNA)在人脑胶质瘤中的表达及意义.方法用免疫组织化学手段检测114例不同级别脑胶质瘤组织中p16和p53、PCNA蛋白的表达,并其与肿瘤不同级别的关系.结果 p16蛋白表达缺失在Ⅲ级(65.6%)、Ⅳ级(91.3%)脑胶质瘤中显著高于Ⅰ～Ⅱ级的缺失(33.3%)(P＜0.01);p53蛋白表达在Ⅲ级(68.8%)、Ⅳ级(89.1%)脑胶质瘤中显著高于Ⅰ～Ⅱ级的表达(27.8%)(P＜0.01); PCNA蛋白的表达在Ⅲ级(56.3%)、Ⅳ级(84.8%)脑胶质瘤中的表达强度显著高于Ⅰ～Ⅱ级(16.7%)的表达强度(P＜0.01).结论 p16 和p53、PCNA蛋白表达异常可用以判断人脑胶质瘤的生物学行为.
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