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Effects of aspirin on the expression of transforming growth factor-β1 in the kidney of diabetic rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-1372.2006.05.004
- Key Word:
- 阿司匹林;糖尿病肾病;转化生长因子β
Abstract： 目的研究阿斯匹林对糖尿病大鼠肾脏的保护作用的机制.方法用链脲佐菌素诱导糖尿病大鼠动物模型,给予阿斯匹林10 mg·kg-1·d-1治疗共6周.测定尿白蛋白排泄量、Ccr、肾组织光镜和电镜检查了解组织形态,肾组织免疫组化检查观察阿斯匹林对糖尿病大鼠肾脏皮质TGF-β1表达影响.结果治疗6周后,阿斯匹林治疗组糖尿病大鼠的Ccr下降,尿白蛋白排泄量无明显下降,光镜下和电镜下系膜区基质增生明显减轻,肾脏皮质肾小球系膜区TGF-β1免疫染色强度比未治疗明显减轻(P＜0.05).结论阿斯匹林对糖尿病大鼠肾脏有保护作用,其机制与抑制糖尿病大鼠肾小球系膜区TGF-β1蛋白过度表达有关.
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- [2]F N, Ziyadeh,D C, Han.Involvement of transforming growth factor-beta and its receptors in the pathogenesis of diabetic nephrology.[J].1997,60.
- [3]王海燕.肾脏病学[M].1998.