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Protective effects and mechanism of Pentoxifylline on rats with renal interstitial fibrosis following unilateral ureteral obstruction
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-1372.2006.05.002
- Key Word:
- 己酮可可碱;肾小球硬化症,病灶性;血管内皮生长因子类;骨形态发生蛋白质类;转化生长因子β;NF-κB;金属蛋白酶类组织抑制剂
Abstract： 目的观察己酮可可碱(PTX)对单侧输尿管梗阻(UUO)大鼠模型肾间质纤维化的作用及其机制.方法假手术组(A);模型组(B);依那普利组(C);PTX组(D);PTX和依那普利组(E).术后第3、7和14天随机处死每组中的5只;测肾组织匀浆中羟脯氨酸浓度,计算胶原/肾重比;免疫组化技术测:CD34(计数肾小管周围毛细血管指数(PCI))、VEGF、BMP-7、TGF-β1、NF-κB、TIMP-1表达量并观察肾病理改变.结果 B组胶原/肾重比高于另外4组.PCI B组第7天(D7)低于其他各组,VEGF表达D14 B组低于D和E组(P均＜0.05).B组D7 BMP-7表达低于3个治疗组;NF-κB:各时间点B组高于其他各组(P均＜0.05),TGF-β1 D14 E组低于C组(P＜0.05),TIMP-1表达D3和D7 B组高于3个治疗组(P均＜0.05).结论 PTX通过维护肾间质微血管系统完整,改善肾间质血供;增加抗纤维化因子、抑制促纤维化因子的表达,减轻肾间质纤维化而保护肾脏,其疗效与依那普利相当.
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