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Study on the expression of nuclear factor-κB in nephridial tissue and the protective role of irbesartan on diabetic nephropathy in rats

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Author:
No author available
Journal Title:
JOURNAL OF CHINESE PHYSICIAN
Issue:
1
DOI:
10.3760/cma.j.issn.1008-1372.2006.01.005
Key Word:
糖尿病肾病;NF-κB;血管紧张素Ⅱ1型受体拮抗剂

Abstract: 目的观察伊贝沙坦对糖尿病肾病的防治作用.方法观察伊贝沙坦干预的糖尿病大鼠的肾组织形态学改变,检测肾组织NF-κB活性,测定血清TNF-α水平.结果伊贝沙坦干预的糖尿病大鼠的肾组织形态学改变明显优于无干预组,肾小球基底膜厚度、肾小球内细胞数和单个核细胞数显著少于对照组,NF-κB活性、TNF-α水平与基底膜厚度呈正相关.结论伊贝沙坦可能通过抑制NF-κB,减轻过度的炎症反应而延缓DN的发生发展.

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