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A study on relationship between the endothelial constitutive nitric oxide synthase gene polymorphism and the coronary disease in patients with type 2 diabetes

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Author:
No author available
Journal Title:
JOURNAL OF CHINESE PHYSICIAN
Issue:
1
DOI:
10.3760/cma.j.issn.1008-1372.2006.01.003
Key Word:
糖尿病,2型;糖尿病并发症;冠状动脉疾病;一氧化氮合酶;多态现象,遗传

Abstract: 目的探讨汉族人内皮固有型一氧化氮合酶(ecNOS)基因外显子7单核苷酸多态性(G894T)和内含子4可变数目串联重复序列插入/缺失多态性(4b/a)与2型糖尿病(T2DM)并发冠心病的关联性.方法提取80例T2DM患者、92例T2DM并发冠心病患者及119例健康人的基因组DNA,用聚合酶链反应-限制片段长度多态性法测定G894T多态性,用聚合酶链反应-可变数目串联重复序列法测定4b/a多态性.结果 3组间G894T多态性基因型(χ2= 11.112,P=0.004)和等位基因(χ2=12.262,P=0.002)频率分布存在统计学差异;3组间4b/a多态性基因分布无差别;携带T等位基因的T2DM患者较之GG基因型者发生冠心病的危险性升高(OR=3.293, P=0.005).结论 ecNOS基因894位点T等位基因是T2DM并发冠心病的独立危险因素.4b/a多态性与T2DM或T2DM并发冠心病无关.

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