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Association of PAI-1 gene polymorphisms with the femoral artery intima-media thickness in patients with type 2 diabetes

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Author:
No author available
Journal Title:
JOURNAL OF CHINESE PHYSICIAN
Issue:
1
DOI:
10.3760/cma.j.issn.1008-1372.2006.01.002
Key Word:
糖尿病,2型;纤溶酶原激活物抑制物1;股动脉;血管中膜

Abstract: 目的探讨人类纤溶酶原激活物抑制物-1 (PAI-1) 基因4G/5G多态性与2型糖尿病(T2DM)患者股动脉内中膜厚度(FA-IMT)的关系.方法采用等位基因特异性多聚酶链式反应技术检测303例T2DM患者和93例健康个体PAI-1 基因4G/5G多态性,利用B型超声检测T2DM患者FA-IMT同时检测其代谢指标.结果 303例T2DM患者与93例健康对照基因型分布频率均符合Hardy-Weinberg氏平衡;健康对照组与T2DM组2组患者PAI-1基因型及等位基因频率比较差异无统计学意义(P>0.05);PAI-1各基因型人群的一般资料、代谢指标和FA-IMT等相比较差异无统计学意义(P>0.05).结论 PAI-1 4G/5G基因型多态性可能不是致T2DM的遗传易感因素,也可能不是致T2DM患者FA-IMT的遗传易感因素.

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