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Association of Angiotensin I-converting enzyme Gene Polymorphisms with the Carotid Intima-media Thickness in Type 2 Diabetes Mellitus

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Author:
No author available
Journal Title:
JOURNAL OF CHINESE PHYSICIAN
Issue:
10
DOI:
10.3760/cma.j.issn.1008-1372.2005.10.004
Key Word:
2型糖尿病;动脉粥样硬化;基因多态性;血管紧张素转换酶基因;股动脉

Abstract: 目的探讨人类血管紧张素转换酶(ACE) 基因插入/缺失多态性(I/D)与2型糖尿病(T2DM)患者股动脉内中膜厚度(FA-IMT)的关系.方法 采用限制性片段长度多形态多聚酶链式反应(PCR-RFLP)技术检测了303例T2DM患者和93例健康个体 ACE基因内含子16插入/缺失(I/D)多态性,利用B型超声检测T2DM患者FA-IMT的情况.结果 与健康对照组比较,T2DM患者I等位基因频率显著增高,而D等位基因频率显著降低.携带ACE DD基因型者FA-IMT增厚的比例显著高于携带II及ID基因型者(P<0.01);多元线性逐步回归分析显示,与T2DM患者基线FA-IMT关系密切的指标为年龄、ACE DD基因型、饮酒史.结论 ACE DD基因型是T2DM患者FA-IMT增加的独立的危险因素.

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