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Relationship between the Apoptosis of MNCS and the Expression of Cytokines and Adhesion Molecules in Patients with SLE
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1008-1372.2005.08.002
- Key Word:
- 系统性红斑狼疮;细胞凋亡;细胞因子;单个核细胞
Abstract： 目的观察系统性红斑狼疮(SLE)患儿单个核细胞( MNCS)凋亡的变化,并检测周围血中细胞因子IL-8、IL-6、TNF-α、NO和黏附分子P-选择素(P-sel)、细胞间黏附分子-1(ICAM-1)水平的变化,探讨细胞因子和黏附分子对MNCS凋亡的影响.方法采用流式细胞术检测32例SLE病人和10例健康对照者MNCS的凋亡情况,ELISA法检测细胞因子和黏附分子水平.结果活动期SLE患者MNCS凋亡率明显高于健康对照组和缓解期患者,缓解期患者MNCS凋亡率与对照组无差别,活动期患者周围血中IL-8、IL -6、TNF-α、NO、P-sel 、ICAM-1水平均高于对照组和缓解组,且与MNCS凋亡和病情均呈正相关.缓解组患者IL-8 、IL-6、TNF-α、NO、P-sel和ICAM-1与对照组无显著性差异.结论 SLE患者MNCS凋亡增加,且与病情及疗效密切相关.炎性细胞因子产生过多、免疫细胞黏附分子表达上调可能是导致MNCS凋亡增高的重要机制,通过适度调控细胞因子的分泌和MNCS凋亡有可能会改善SLE预后.
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