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Relationship between the Th1/Th2 Cytokines Imbalance and Autoimmune Thyroid Diseases
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1008-1372.2005.07.005
- Key Word:
- Th1/Th2细胞免疫;细胞因子;自身免疫性甲状腺疾病;抗甲状腺自身抗体
Abstract： 目的分析血清Th1/Th2型细胞因子水平与抗甲状腺自身抗体的相关性,研究甲状腺Th1/Th2细胞免疫失衡与自身免疫性甲状腺疾病(AITD)的发病关系.方法选取21例Graves病(GD)患者、18例桥本甲状腺炎(HT)患者,17例非毒性结节性甲状腺肿(NTNG)患者,20例正常人作为对照进行研究.采用ELISA法检测各组人群血清Th1型细胞因子γ-干扰素(IFN-γ)、白介素2(IL-2)和Th2型细胞因子白介素4(IL-4)、白介素10(IL-10)的含量,并与血清促甲状腺激素受体抗体(TRAb)、甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)水平进行相关分析.结果 GD患者血清IL-4和IL-10水平明显高于HT、NTNG和对照组(P＜0.01);而HT患者血清IFN-γ和IL-2水平明显高于GD、NTNG和对照组(P＜0.01),IL-4水平明显低于对照组(P＜0.05);GD患者血清IL-4和IL-10含量与TRAb水平呈显著正相关(r=0.683, 0.579;P＜0.05);HT患者血清IFN-γ和IL-2水平与TGAb、TPOAb均呈显著正相关(IFN-γ:r=0.542, 0.650;IL-2:r=0.517,0.602;P＜0.05).结论 GD患者Th1/Th2细胞免疫平衡偏向以Th2细胞免疫占优势的免疫应答,而HT患者Th1/Th2细胞免疫平衡偏向以Th1细胞免疫占优势的免疫应答.
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