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Study on Relationship Between Blood Motilin and Anorectal Function in Functional Outlet Obstructive Constipation
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1008-1372.2005.07.003
- Key Word:
- 功能性出口梗阻型便秘;肛管直肠测压;胃动素;相关
Abstract： 目的研究血胃动素及肛管直肠功能改变在功能性出口梗阻型便秘发病中的作用,探讨胃动素及其受体激动剂可否用于治疗出口梗阻型便秘.方法根据结肠运输时间和运输指数选择出口梗阻型便秘患者,设健康对照组,行肛管直肠测压检查,测定血胃动素并分析其与肛管直肠测压指标值的相关性.结果出口梗阻型便秘患者的肛管静息压升高,模拟排便时直肠肛管压差显著降低,引起直肠肛管抑制反射的最小松弛容积及直肠感觉阈值均高于健康人.患者血胃动素无明显变化,胃动素水平与肛管静息压、最大缩榨压及模拟排便时肛管压力成正相关,与模拟排便时直肠肛管压差成负相关.结论出口梗阻型便秘发病基础是肛门括约肌舒张失调,排便时直肠肛管不协调,直肠敏感性低;血胃动素正常便秘患者可能有更多出口梗阻问题,出口梗阻型便秘患者不宜采用胃动素或其受体激动剂治疗.
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