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Rutaecarpine Ameliorates Cerebral Ischemia-reperfusion Injury by Stimulating Calcitonin Gene-related Peptide Release in the Rat Brain
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-1372.2005.05.005
- Key Word:
- 吴茱萸次碱;脑缺血-再灌注损伤;降钙素基因相关肽
Abstract： 目的观察吴茱萸次碱对大鼠脑缺血-再灌注损伤及脑组织降钙素基因相关肽的影响.方法大鼠实验前30min静脉注射吴茱萸次碱(50、100、300μg·kg-1),然后用线栓法制作大鼠局灶性脑缺血-再灌注损伤模型,缺血2h,再灌注24h.于再灌注后6、12、24h进行神经功能缺陷评分;采用TTC染色法测定脑梗死体积;放射免疫法检测脑组织匀浆中降钙素基因相关肽(CGRP)含量.结果吴茱萸次碱呈剂量依赖性减少脑梗死体积并改善功能预后,与溶媒组比较有显著性差异;各吴茱萸次碱治疗组脑梗死后CGRP含量和溶媒组比较显著增高.结论吴茱萸次碱对缺血性脑损伤有明显保护作用,其机制可能与促进脑组织CGRP的释放有关.
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