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Relationship Between Interleukin-6 Gene Promoter Polymorphisms and Plasma Lipid, Platelet Count
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-1372.2005.05.003
- Key Word:
- 白细胞介素-6;基因多态性;血小板;血脂
Abstract： 目的研究白细胞介素-6(IL-6)基因启动子-572C/G、-634C/G多态性在广西地区汉族人群中的分布特点,并探讨其与血脂、血小板计数的关系.方法应用聚合酶链反应-限制性片段长度多态性法(PCR-RFLP)检测198例正常汉族人IL-6基因型,同时检测血小板数量及血脂水平.结果 IL-6的基因型间血脂水平比较差异无显著性(P＞0.05);IL-6 基因-572C/G多态性与血小板数量具有相关性,携带G等位基因的个体血小板数量显著高于不携带者(178.75±49.32×109·L-1 vs 169.87±47.19×109·L-1,P＜0.05),IL-6基因-634C/G多态性与血小板数量无相关性(P＞0.05).结论在广西汉族人群中存在IL-6基因-572C/G、-634C/G多态性;且IL-6 基因-572C/G多态性与血小板数量具有相关性,携带G等位基因的个体血小板数量显著高于不携带者,这在血栓性疾病及动脉粥样硬化预防中具有重要意义.
- [1]孙永年,黄长形,黄祝青.T淋巴细胞亚群、TNF-α、IL-6、IL-8、sIL-2R与乙肝病毒复制的关系[J].2003,(4).
- [2]李丽.急性脑出血患者血清TNF-α、IL-6、NO的动态监测及临床意义[J].2003,(12).
- [3]Lowe GD,Montgomery HE,Humphries SE,etc.Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery.[J].2001,21(9).
- [4]Ricart W,Broch M,Richart C,etc.Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects.[J].2000,85(3).