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The Effect of Proglumide on Pancreatic Function of Post-ERCP
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1008-1372.2005.04.003
- Key Word:
- 丙谷胺;胆囊收缩素;ERCP;胰腺炎
Abstract： 目的探导丙谷胺对逆行胰胆管造影(ERCP)术后胰腺功能的影响.方法比较对照组(S组)、奥曲肽组(O组)、丙谷胺组(P组)急性胰腺炎的发生率、死亡率、血浆胆囊收缩素八肽(CCK-OP)及血清淀粉酶含量的变化.结果 S组并发急性胰腺炎3例(13.6%,3/22),O组并发急性胰腺炎1例(5%,1/20),P组并发急性胰腺炎1例(4.0%,1/25),S组明显高于O组及P组(P＜0.05).术后6h及24h P组及O组血清淀粉酶与S组比较差异均有显著性(P＜0.05), 但P组与O组比较差异无显著性(P＞0.05).术后6h P组血浆CCK-OP 明显低于O组及S组,差异有显著性(P＜0.05).术后24h P组与O组及S组比较差异均无显著性(P＞0.05).结论丙谷胺可抑制CCK-OP的作用,与奥曲肽一样能有效地保护ERCP术后胰腺的功能,减轻酶血症,预防急性胰腺炎的发生.
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