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The Elimination Effect of Propofol on Reactive Oxygen Species in Patients with Acute Craniocerebral Injury
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1008-1372.2005.04.002
- Key Word:
- 急性颅脑损伤;活性氧;丙泊酚
Abstract： 目的观察丙泊酚(pro)对急性颅脑损伤(ACI)患者开颅手术期间体内活性氧(ROS)的清除作用.方法 ACI患者40例.根据麻醉方法不同随机分为观察组(pro组)和对照组(γ-OH组).以电子自旋共振(ESR)方法测定血内氧自由基(OFR);用化学方法测定一氧化氮(NO)、脂质过氧化物(LPO)含量.观察时间为麻醉诱导前、开颅手术去骨瓣后2、4h(分别用T0～T2表示).并以40例健康者作为术前对照.结果术前患者NO、OFR、LPO显著高于正常对照组(均P＜0.01).γ-OH组T1时患者血中NO、OFR、LPO显著高于T0(均P＜0.01).T2时OFR、LPO较T1呈显著升高,NO显著降低(均P＜0.01).pro组NO自始至终(T0～T2)呈降低趋势,于T2时达到正常水平.较T0呈显著性降低(P＜0.01).OFR、LPOT1较T0呈显著性升高(均P＜0.05).T2较T0呈显著性降低(均P＜0.01).结论 ACI患者术前就存在ROS代谢紊乱及开颅手术可导致继发性脑缺血再灌注损害.临床麻醉剂量的pro在人体内具有直接清除ROS特性,可对脑损伤患者提供脑保护作用.
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