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Relationship between the p33ING1b Protein Expression and Differentiated Degree in Human Gastric Carcinoma
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1008-1372.2005.02.004
- Key Word:
- p33ING1b蛋白;胃癌;分化程度;免疫组化
Abstract： 目的研究ING1基因表达产物P33ING1b蛋白在胃癌中的表达,分析ING1基因表达与胃癌分化程度的关系.方法采用S-P免疫组化法,检测P33ING1b蛋白在不同分化程度胃癌及正常胃粘膜组织中的表达状况.结果 P33ING1b蛋白在胃癌中的阳性表达率为:高分化胃癌75%(15/20);中分化胃癌55%(11/20);低分化胃癌15%(3/20);正常胃粘膜组织P33ING1b蛋白均为阳性表达(100%,60/60).胃癌组织中P33ING1b蛋白阳性表达率低于正常胃粘膜,差异有显著性意义(P＜0.05);P33ING1b蛋白在胃癌中的表达率随着其分化程度的降低而减少(P＜0.05).结论胃癌组织中存在P33ING1b蛋白表达缺失,其表达缺失率与胃癌分化程度有关.
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