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A Study on the Effect of IL-2 Therapy on Chemotherapeutic Sensitivity in Hepatocelluar Carcinoma
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1008-1372.2005.01.005
- Key Word:
- 肝肿瘤;多药耐药相关蛋白;白细胞介素-2
Abstract： 目的研究IL-2治疗与肝细胞癌化疗敏感性的关系.方法采用S-P免疫组织化学方法对14例术前有IL-2治疗史、12例术前没有IL-2治疗史的肝细胞癌存档石蜡包埋切片组织中MRP1、IL-2受体α链的表达进行检测.结果 IL-2治疗组中IL-2受体α链表达强度为:0.3019±0.04023,明显高于非治疗(0.2631±0.02224,P＜0.01),IL-2治疗组IL-2治疗有效.IL-2治疗组中MRP1表达的强度为:0.3364±0.04467,非治疗组为:0.3008±0.03764,两者的差异有显著性意义(P＜0.05).结论用IL-2治疗HCC患者,在增加机体抗肿瘤免疫的同时增加了肝癌细胞对化疗药物的耐受性,因此,在以化疗为主要治疗手段时,联合应用IL-2会降低治疗效果.
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