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The Clinical Significance of MVD and PCNA Expression in Cervix Squamous Cell Carcinoma
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1008-1372.2005.01.004
- Key Word:
- 微血管密度;细胞增殖核抗原;子宫颈鳞癌;淋巴结转移
Abstract： 目的研究微血管密度(MVD)和增殖细胞核抗原(PCNA)与子宫颈鳞癌生长、浸润及转移的关系.方法采用免疫组化(S-P法)及组织病理学等方法,检测32例子宫颈鳞癌组织中CD34和PCNA的表达,并计算出微血管密度(MVD)和增殖指数(PI).结果 PI、MVD与肿瘤的分化程度、FIGO临床分期有密切关系.低分化程度组和高FIGO临床分期组PI、MVD值明显高于高分化程度组、及低FIGO临床分期组(P＜0.01);淋巴结转移组PI、MVD明显高于无淋巴结转移组(P＜0.01),且MVD与PI密切相关.(r=0.861,P＜0.01).结论血管形成参与了子宫颈鳞癌的形成;MVD和PCNA与子宫颈鳞癌恶性程度密切相关.
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