The Relation Between Serum MIS Values and Deformities of Urogenital System in Children
- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- z1
- DOI:
- 10.3760/cma.j.issn.1008-1372.2004.z1.001
- Key Word:
- 苗勒氏抑制物质;睾酮;泌尿生殖器畸形;小儿
Abstract： 目的探讨小儿血清苗勒氏抑制物质(Mullerian Inhibiting Substance,MIS)水平变化与小儿泌尿生殖器畸形的关系.方法通过测定我院非泌尿生殖器疾病的2～14岁男、女病人,隐睾病人血清MIS、睾酮(Testosterone ,T)值了解⑴男、女体内MIS值的区别、变化规律;⑵MIS和T值的关系;⑶隐睾病人血清MIS值与非泌尿生殖器疾病病人血清MIS值的变化.结果⑴男性非泌尿系统疾病病人血清MIS值1岁后呈逐渐下降曲线,均值从(797.03±246.12)pmol/L至(81.74±38.40)pmol/L有统计学意义(P＜0.01).⑵睾酮在青春发育期前很低,至青春发育期开始升高(P＜0.01).并且用S-N-K法组间比较发现从13岁起T值有明显的上升(P＜0.05).⑶非泌尿系统男性病人血清睾酮和其MIS变化呈负相关,r= -0..314,P＜0.05.⑷1～14岁非泌尿系统女性病人血清MIS值最高52.87pmol/l,最低为0 pmol/L,平均16.38 pmol/L.各年龄段之间无明显差异(P>0.05).但性别对于MIS值有非常显著的影响(排除年龄影响因素)(P＜0.01).⑸隐睾病人的 MIS值与同龄儿相比较,1～11岁无明显差别(P>0.05),12～14岁有显著性差异(P＜0.05).结论 MIS由男性睾丸塞托利细胞及女性卵巢颗粒细胞分泌,T由睾丸来迪希细胞分泌.因此MIS、T值的水平可以间接反映睾丸塞托利细胞和来迪希细胞的发育情况.本实验结果1～14岁男孩血清MIS值呈逐渐下降趋势.MIS对出生后睾丸的发育起直接的调节作用.本实验发现隐睾病人青春发育前期血清MIS与同年龄的对照组相比,有统计学意义.1～14岁男、女性血清MIS值有明显的差异.女性体内血清MIS异常的增高应被怀疑体内有睾丸或颗粒细胞瘤的可能.男性体内MIS值过低应被怀疑生殖器发育不良或睾丸缺如及体内有卵巢存在等可能.因此通过测定血清MIS值可以了解双侧阴囊、腹股沟未触及睾丸病人及两性畸形病人体内是否有睾丸的存在.
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