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The Effect of Pravastatin on Impaired Endothelium-dependent Relaxation of Isolated Rabbit Aortic Rings Induced by Homocysteine
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1008-1372.2004.12.005
- Key Word:
- 普伐他汀;同型半胱氨酸;内皮依赖性舒张;胸主动脉;兔
Abstract： 目的探讨普伐他汀(pravastatin, PT)对同型半胱氨酸(homocysteine, Hcy)损伤家兔离体胸主动脉内皮依赖性舒张功能的影响.方法采用离体胸主动脉环方法检测乙酰胆碱诱导的内皮依赖性舒张反应来评价Hcy对血管内皮功能的损害和PT的保护作用. 结果分别用1～10mmol/L Hcy孵育血管环30min,呈浓度依赖性地抑制乙酰胆碱诱导的内皮依赖性舒张反应.用0.3～3mmol/L PT分别预孵育血管环15min,再与3mmol/L Hcy共孵育30min,则显著改善Hcy所致的血管舒张功能的损害,并有剂量依赖性.结论这些结果提示,PT对Hcy所致血管内皮依赖性舒张功能的损伤具有明显的保护作用. 基金项目:卫生部"九五"攻关资助项目(96-906-03-06)
- [1]邓华菲,熊燕.他汀类药物的非降脂作用与心血管保护[J].2004,(4).
- [2]Fu SH,Xiong Y,Fu YF.Captopril restores endothelium-dependent relaxation of rat aortic rings after exposure to homocysteine.[J].2003,42(4).
- [3]Heistad DD,Piegors DJ,Lentz SR,etc.Supplementation of atherogenic diet with B vitamins does not prevent atherosclerosis or vascular dysfunction in monkeys.[J].2001,103(7).
- [4]A H, Wagner,T, K?hler,U, Rückschloss,etc.Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation.[J].2000,20(1).
- [5]R H, B?ger,S M, Bode-B?ger,K, Sydow,etc.Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia.[J].2000,20(6).
- [6]Hayashi T,Thakur NK,Sumi D,etc.Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days.[J].2001,104(4).
- [7]Markus Stü,hlinger,Roberta Oka,etc.Endothelial Dysfunction Induced by Hyperhomocyst(e)inemiaRole of Asymmetric Dimethylarginine[J].2003,108(8).
- [8]Moisés, Alvarez-Maqueda,Rajaa, El Bekay,Javier, Monteseirín,etc.Homocysteine enhances superoxide anion release and NADPH oxidase assembly by human neutrophils. Effects on MAPK activation and neutrophil migration.[J].2004,172(2).