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The Effect of Jianweiyuyang Granule on Gastric Ulcer and Expression of VEGF and PDGF in Rat
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1008-1372.2004.12.003
- Key Word:
- 健胃愈疡颗粒;胃溃疡;溃疡指数;VEGF;PDGF;大鼠
Abstract： 目的研究健胃愈疡(Jianweiyuyang, JWYY)颗粒对溃疡的影响,并探讨其机制.方法以Okabe改良法复制大鼠实验性胃溃疡,观察其对溃疡指数和溃疡组织学的影响,并用免疫组化法观察血管内皮生长因子(VEGF)、血小板源性生长因子(PDGF)表达的变化. 结果 JWYY颗粒能提高VEGF、PDGF表达,明显降低溃疡指数,增加黏膜厚度,促进溃疡愈合.结论 JWYY颗粒通过提高VEGF、PDGF表达,提高溃疡愈合质量,这可能是其促进溃疡愈合的机制之一.
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