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The Differential Expression of p53, VEGF and MVD in Breast Cancer and Tumor Adjacent Tissues and Its Clinical Significance
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1008-1372.2004.10.001
- Key Word:
- 乳腺癌;免疫组化;p53;VEGF;MVD
Abstract： 目的检测抑癌基因p53,血管内皮生长因子(VEGF)和微血管密度(MVD)在乳腺癌及乳腺癌旁组织中的表达,探讨其相关性及其在乳腺癌发生发展过程中的作用.方法采用免疫组织化学SP法检测110例乳腺癌及其癌旁乳腺组织中p53,VEGF表达水平,比较MVD的大小.结果VEGF,p53在乳腺癌组织中的阳性表达率分别为90.0%(99/110),42.7%(47/110);癌旁乳腺组织中阳性表达率则分别为35.5%(39/110),4.5%(5/110),两者间具有高度显著性差异(P＜0.01).乳腺癌组织微血管密度MVD均值为(16.4±12.3),癌旁乳腺组织则为(7.3±6.8),两者间具有高度显著性差异(P＜0.01).MVD值在p53、VEGF阳性表达的组织中明显高于p53、VEGF阴性表达的组织,二者比较差异显著(P＜0.01、P＜0.05).结论联合检测p53、VEGF和MVD的表达可作为判断乳腺癌生物学行为和预后的重要指标.
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