You Position: Home > Paper
A Clinical Study on the Level of Lymphocyte Sub-population and NK Cell in Patients with Primary Lung Malignant Tumor and COPD Patients
( views:218, downloads:4 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1008-1372.2004.08.002
- Key Word:
- 淋巴细胞亚群;原发性肺部恶性肿瘤;慢性阻塞性肺部疾病
Abstract： 目的探讨原发性肺部恶性肿瘤与慢性阻塞性肺部疾病(COPD)患者外周血淋巴细胞亚群及NK细胞水平测定的临床价值.方法应用单克隆抗体-碱性磷酸酶抗碱性磷酸酶法(APAAP法)测定60例COPD病人,50例原发性肺部恶性肿瘤病人和40例正常对照组CD3+,CD4+,CD8+,CD19+及NK细胞的百分数,计算CD4+/CD8+比值.结果原发性肺部恶性肿瘤组、COPD组的CD3+,CD4+,CD4+/CD8+,CD19+明显降低,而CD8明显增高,与对照组比较均有显著差异(P＜0.01);原发性肺部恶性肿瘤组的NK细胞的百分数降低,与对照组比较有显著差异(P＜0.01),COPD组NK表达与对照组比较无显著差异(P＞0.05).原发性肺部恶性肿瘤组与COPD组的CD3+,CD4+,CD8+均无明显差异(P＞0.05),而NK,CD19+有差异(P＜0.01). 结论原发性肺部恶性肿瘤组和COPD组存在细胞免疫功能紊乱和失调,临床上应不失时机的应用免疫调节剂.
- [1]萧正华,廖军,刁学廉.糖尿病合并肺部感染时免疫功能改变及防治感染的重要性[J].2000,(5).
- [2]J A, Allay,J E, Dennis,S E, Haynesworth,etc.LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors.[J].1997,8.
- [3]贾战生,于兰.T淋巴细胞亚群的检测及其临床意义[J].1992,(4).
- [4]田志刚,孙汭.CD4~+T和CD8~+T细胞的新功能[J].1997,(3).
- [5]Zuin R,Turato G,Saetta M.Pathogenesis and pathology of COPD.[J].2001,68(2).
- [6]D M, Kemeny,B, Vyas,M, Vukmanovic-Stejic,etc.CD8(+) T cell subsets and chronic obstructive pulmonary disease.[J].1999,160.
- [7]孔灵菲,刘德云,李丽云,等.肺癌病人外周血T淋巴细胞亚群、NK活性和IL-2水平的研究[J].1998,(2).