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A Study on the Correlation between the Polymorphism of GSTM1 and GSTT1 Genes and Susceptibility to the Development of COPD
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1008-1372.2004.06.001
- Key Word:
- GSTM1、GSTT1基因型;纯合性缺失;COPD;易感性;多态性
Abstract： 目的探讨GSTM1、GSTT1基因多态性与COPD易感性的关系.方法应用PCR技术对91例COPD患者和44例非COPD人群GSTM1、GSTT1不同基因型进行检测并根据性别、年龄及吸烟史对其易感性进行分析.结果两组之间相比较男性及＞40岁的人群其GSTM1 0/0基因型频率有显著性差异(P＜0.05);在吸烟指数为≥31PY时,COPD组的GSTM1 0/0基因型频率显著高于对照组(P＜0.05);根据性别、年龄组及吸烟史分析,在两组人群中GSTT1 0/0基因型频率均未发现有显著性差异(P值均＞0.05);两组人群综合基因型频率分析显示,在吸烟指数≥31PY的人群中GSTM1 0/0-GSTT1 0/0基因型频率则显著高于对照组(P＜0.05).结论 GSTM1纯合缺失基因型可能增加了长期大量吸烟人群对COPD的易感性,若同时伴有GSTT1的纯合性缺失可进一步增加对COPD的易感性.
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