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Study on the Expression of LMP1,CyclinD1 and Bcl-2 in Nasopharyngeal Carcinoma and Its Clinical Significance
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-1372.2004.05.006
- Key Word:
- 潜伏膜蛋白;Bcl-2;细胞周期素;鼻咽癌
Abstract： 目的探讨LMP1,cyclinD1和Bcl-2在鼻咽癌中的表达及临床意义,并分析其表达间的相关性.方法用免疫组化SP法分别检测LMP1,cyclinD1和Bcl-2在60例鼻咽癌组织中的表达.结果⑴LMP1,cyclinD1和Bcl-2在鼻咽癌组织中的阳性表达率分别为65%(39/60)、60%(36/60)和65%(39/60);⑵LMP1,cyclinD1和Bcl-2阳性和阴性病例的平均生存期、五年生存率和中位生存期存在显著性差异(P＜0.05);⑶鼻咽癌组织中CyclinD1和Bcl-2的表达一致率为68.33%(41/60),存在显著相关性(r=0.399,P＜0.01),LMP1与Bcl-2,LMP1与CyclinD1间无显著相关.⑷LMP1、CyclinD1阳性表达在鼻咽癌不同临床时期(Ⅱ、Ⅲ、Ⅳ)存在显著差异(P＜0.01).结论 LMP1可能独立地预测鼻咽癌预后而cyclinD1、Bcl-2表达情况可综合预测鼻咽癌预后.
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