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Effect of Herpes Simplex Virus-2 Infection on the HLA Class Ⅱ Antigen Expression of Human Monocytes
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1008-1372.2004.04.006
- Key Word:
- 单纯疱疹病毒2型;单核细胞;HLA-Ⅱ类抗原
Abstract： 目的研究单纯疱疹病毒2型(HSV-2)对人单核细胞表达HLA-Ⅱ类抗原(HLA-DR、HLA-DQ)的影响,探讨单核细胞及HLA-Ⅱ类抗原在单纯疱疹病毒2型感染中的作用.方法用单纯疱疹病毒2型(333株)感染人单核细胞,于感染后1、3、5、7d分别收集细胞,用APAAP法检测单核细胞HLA-DR、HLA-DQ表达水平.结果单纯疱疹病毒2型感染后1,单核细胞表达HLA-DR、HLA-DQ抗原水平明显降低,以后均逐渐升高,至7d达到对照组水平.结论单纯疱疹病毒2型感染早期能抑制单核细胞表达HLA-Ⅱ类抗原,HSV-2抑制单核细胞表达HLA-II类抗原可能是HSV-2逃避机体的手段之一.HLA-Ⅱ类抗原在单纯疱疹病毒2型致病及免疫过程中可能起重要作用.
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