You Position: Home > Paper
The Clinical Research on the Changes of Urinary Deoxypyridinoline in Bedridden Fracture-patients with Long-term Treament
( views:185, downloads:8 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1008-1372.2004.04.005
- Key Word:
- 骨折;骨代谢;骨质疏松;尿脱氧吡啶啉
Abstract： 目的探讨骨折长期固定治疗患者尿脱氧吡啶啉的变化及其临床意义.方法测定37例(男22例,女15例)骨折长期固定治疗患者及30例(男15例,女15例)健康对照者的血清钙(Ca)、磷(P)、总碱性磷酸酶(AKP)、尿钙/肌酐(Ca/Cr)、尿脱氧吡啶啉(DPD)的水平.结果骨折长期固定治疗患者血清钙、磷水平较正常对照组显著降低(P＜0.05);AKP、Ca/Cr、DPD水平较正常对照组有不同程度的增高(P＜0.05,P＜0.05和P＜0.01).其中以尿DPD的活性增高更为显著(增高5.98倍).而且,骨折长期固定治疗患者尿DPD的变化还与病程呈正相关.结论尿DPD是反映骨吸收的一项敏感而特异的指标,尿DPD的监测对骨折长期固定治疗患者的临床治疗和预防发生新的骨折具有重要的参考价值.
- [1]金世鑫.钙磷代谢疾病[J].2001,(4).
- [2]Anne M. Delany,Yu Dong,Ernesto Canalis.Mechanisms of glucocorticoid action in bone cells[J].1994,56(3).
- [3]M, Bonde,P, Qvist,C, Fledelius,etc.Immunoassay for quantifying type I collagen degradation products in urine evaluated.[J].1994,40.
- [4]M I, Gerrits,J H, Thijssen,H J, van Rijn.Determination of pyridinoline and deoxypyridinoline in urine, with special attention to retaining their stability.[J].1995,41.
- [5]S L, Yu,L M, Ho,B C, Lim,etc.Urinary deoxypyridinoline is a useful biochemical bone marker for the management of postmenopausal osteoporosis.[J].1998,27.
- [6]Ross PD,Knowlton W.Rapid bone loss is associated with increased levels of biochemical markers.[J].1998,13(2).
- [7]Sano M,Kushida K,Takahashi M,etc.Urinary pyridinoline and deoxypyridinoline in prostate carcinoma patients with bone metastasis[J].1994.
- [8]袁敏敏.骨吸收三种尿生化指标的敏感性比较[J].1998,(4).