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Investigation of Drug-Resistance and the Genotypes of Extended-spectrum β-Lactamases Producers

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Author:
No author available
Journal Title:
JOURNAL OF CHINESE PHYSICIAN
Issue:
1
DOI:
10.3760/cma.j.issn.1008-1372.2004.01.005
Key Word:
超广谱β-内酰胺酶;耐药性;聚合酶链反应;序列分析

Abstract: 目的了解北京天坛医院和北京朝阳医院产超广谱β-内酰胺酶(ESBLs)菌株的耐药情况,并对携带的ESBLs基因型进行调查.方法对52株大肠埃希菌、肺炎克雷伯菌进行琼脂稀释法、等电点测定和聚合酶链反应克隆测序.结果产ESBLs菌株对多种抗生素耐药;克隆测序分别为CTX-M-14、22、24和SHV-2、12型.结论密切监控ESBLs菌株的产生,追踪调查其基因型,对防止产ESBLs菌株的区域性流行和指导临床合理应用抗生素有重要意义.

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