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Effects of Early Enteral Feeding Containing MCT/LCT on Improving Protein Catabolism of Burned Patients
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1008-1372.2003.12.003
- Key Word:
- 早期肠内营养;烧伤;中链脂肪;肠道
Abstract： 目的通过比较烧伤病人早期肠内喂养含MCT/LCT与只含LCT的肠内营养制剂对烧伤后高代谢的不同影响,探讨MCT/LCT改善烧伤后代谢状态的作用及可能机制.方法选取30例TBSA＞30%的烧伤病人,并随机分为两组,一为Fresubin 750MCT组(F组),即饲以含MCT/LCT 的肠内营养制剂Fresubin 750MCT;另一组为Nutrison组(N组),即饲以只含LCT的肠内营养制剂Nutrison.于伤后24h内进行完全肠内营养支持,共支持10d.在PBD1、4、7、10分别观察了两组患者影响代谢的严重因子的变化情况(包括血浆胰岛素、胰高血糖素、肿瘤坏死因子(TNF)及皮质醇.尿3-甲基组氨酸排泄率).结果烧伤后机体分解代谢增加,两组相比血浆皮质醇水平无显著差异;F组患者血浆胰岛素与胰高血糖素浓度的比值明显升高,尿3-甲基组氨酸排泄率及血浆TNF明显下降.结论含MCT/LCT的肠内营养制剂较只含LCT者,能促进烧伤后机体合成激素的分泌,减少肌肉蛋白分解排出量,从而改善烧伤病人代谢状况,并有利于提高全身营养及免疫状况,促进创面愈合.
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