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Paraoxonase 1 Gene Expression Is Associated with Chronic Renal Failure in the Hans of Hunan Province
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1008-1372.2003.10.003
- Key Word:
- 二乙基对硝基苯磷酸酯酶I型基因;慢性肾衰;多态性
Abstract： 目的探讨血清PON 1酶活性、PON 1 Q192R 基因多态性与湖南汉族慢性肾衰病人的关系.方法对79例湖南汉族慢性肾衰病人及90例对照组的血清PON 1酶蛋白水平、 PON 1 Q192R基因多态性进行检测.结果慢性肾衰病人组血清PON 1酶活性(372.6±150.6)U显著低于对照组(537.8±172.2)U,两者比较,差异有显著性(P＜0.01) ;慢性肾衰病人组PON 1 AB+BB基因型频率明显高于对照组,基因型AB+BB/AA的优势比为6.39(95%可信限为2.50～16.35,P＜0.01) .结论 PON 1基因表达与湖南汉族人慢性肾衰疾病发生有关,AB+BB基因型可能系慢性肾衰疾病中的危险因子.
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