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Effect of Percutaneous Coronary Intervention on Plasma Tissue Factor Pathway Inhibitor
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1008-1372.2003.07.002
- Key Word:
- 冠心病;经皮冠状动脉球囊成形术;支架;组织因子途径抑制物
Abstract： 目的探讨冠状动脉介入治疗对冠心病患者冠脉循环前后组织因子途径抑制物(TFPI)的影响.方法用酶联免疫吸附法(ELISA)检测42例冠心病患者经皮冠状动脉球囊成形和/或支架植入术前、术后冠状静脉窦(CS)和冠状动脉窦(CA)血浆TFPI含量,同时发色底物法测定其活性.结果冠脉介入治疗术前冠状静脉窦比冠状动脉窦血浆TFPI含量明显升高(P＜0.05),但术后冠状静脉窦与冠状动脉窦血浆TFPI活性比较无显著性差异(P＞0.05);术后冠状静脉窦和冠状动脉窦血浆TFPI含量与活性均较其术前明显升高(P＜0.05).结论冠心病患者冠脉循环后血浆TFPI含量升高,冠脉介入治疗术后其含量与活性明显增加,TFPI发挥抗凝、抗血栓作用.
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