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Serologic Presentation of Helicobacter Pylori Infection in Patients With Inflammatory Bowel Disease
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1008-1372.2003.06.006
- Key Word:
- 炎症性肠病;Crohn病;溃疡性结肠炎;幽门螺杆菌
Abstract： 目的研究幽门螺杆菌(Hp)在炎症性肠病(IBD)患者中的血清学表现以及Hp在IBD发生中的作用.方法以慢性胃炎为对照配对(性别相同、年龄相似)检测4年间IBD患者血清中抗-Hp-IgG和抗-Hp-CagA并分析它们与溃疡性结肠炎(UC)病变范围的关系.结果 IBD患者共45例,其中UC 40例,Crohn病(CD)5例;抗-Hp-IgG(+)率IBD患者(40.0%)较慢性胃炎(66.7%)低(χ2＝6.43,P＜0.05),其中UC患者及其对照分别为42.5%和65.0%(χ2＝4.07,P＜0.05),CD患者抗-Hp-IgG(+)者为1/5;UC患者中抗-Hp-IgG(+)率全结肠受累者(28.0%)比部分结肠受累者(66.7%)低(χ2＝5.74,P＜0.05);抗-Hp-CagA(+)率在IBD及其对照分别为28.9%和40.0%(P＞0.05),全结肠和部分结肠受累的UC患者分别为28.0%和40.0%(P＞0.05).结论 IBD患者中抗-Hp-IgG(+)率处于较高水平,但比慢性胃炎低;Hp感染对UC的病变范围可能有抑制作用;IBD患者及全结肠受累的UC患者抗-Hp-CagA(+)率较低,但差异无显著性.
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