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Clinical Significance of the Expression of Apoptosis and p53 in Lung Cancer
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-1372.2003.05.006
- Key Word:
- 肺癌;化疗;凋亡;p53
Abstract： 目的探讨化疗对肺癌细胞凋亡、p53蛋白表达的影响.方法收集实验组14例肺癌病人化疗前后标本和对照组术前未作化疗肺癌标本28例,采用免疫组化法检测p53蛋白表达,采用TUNEL法检测细胞凋亡, 并作化疗前后的比较.结果对照组和实验组在化疗前后p53阳性表达无显著差异(P＞0.05),而化疗后凋亡指数明显升高(P＜0.01).结论化疗可诱发肺癌细胞凋亡, 但对p53蛋白表达没有影响.
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