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Alternation and Significance of P-selectin in Plasma During Rats Traumatic Shock
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-1372.2003.05.002
- Key Word:
- 休克,创伤性;P-选择素;NO;L-Arg
Abstract： 目的探讨创伤性休克时大鼠血浆中P-选择素的变化及其意义.方法 24只大鼠分为正常对照组,创伤休克组,L-Arg治疗组.复制大鼠创伤性休克模型,采用酶联免疫法(ELISA)测定休克后30min和4h大鼠血浆中P-选择素水平.结果正常大鼠血浆中有P-选择素表达,休克后30min,血浆中P-选择素水平较正常对照组升高,但无明显统计学意义;休克后4h,休克组血浆P-选择素含量显著升高,L-Arg治疗组较休克组P-选择素明显下降.结论创伤性休克可导致血浆中P-选择素大量表达,这与休克时存在明显的微循环紊乱和内皮功能障碍有关.L-Arg 可能通过促进内皮型NO的合成来减少P-选择素的表达.
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