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Alterations of Serum Insulin, True Insulin in Patients With Simple Obesity and Analyses of Factors Affecting Insulin Resistance
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1008-1372.2003.03.006
- Key Word:
- 肥胖症;胰岛素;真胰岛素;胰岛素抵抗
Abstract： 目的观察单纯性肥胖患者血清胰岛素、真胰岛素变化,并分析胰岛素抵抗的影响因素.方法单纯性肥胖者70例,正常对照组30例,均检测身高、体重、腰围、臀围,同时测定血清真胰岛素(TI)、免疫活性胰岛素(IRI)、空腹血糖(FPG)、血甘油三脂(TG)、胆固醇(CHO),计算胰岛素敏感指数(ISI)[ISI1=1/(FPG×TI),ISI2=1/(FPG×IRI)],并对ISI1与各指标进行相关性分析.结果肥胖患者血清胰岛素、真胰岛素水平明显高于对照组(P＜0.01),ISI1、ISI2显著低于对照组(P＜0.01),但ISI1的降低要比ISI2降低明显(P＜0.01);直线相关分析显示,ISI1与BMI、体重、腰围、TG呈负相关,γ依次为-0.678、-0.540、-0.568(P＜0.01),-0.247,(P＜0.05) .多元步回归分析显示影响肥胖患者ISI1的最重要因素是BMI(-0.514)、TG(-0.350)、腰围 (-0.311) (χ2＝0.669, F＝33.814, P＜0.01).去除BMI的影响因素后,ISI1与TG明显负相关(γ＝-0.296,P＜0.05).结论肥胖患者有高胰岛素血症和胰岛素抵抗,真胰岛素水平比免疫活性胰岛素水平更能反映胰岛素抵抗的程度,胰岛素抵抗与BMI、甘油三脂、腰围明显相关.
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